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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Improved anti-inflammatory properties for naproxen with cyclodextrin-grafted polysaccharides
Héctor L Ramírez1, Roberto Cao, Alex Fragoso
1Center for Enzyme Technology, University of Matanzas, Matanzas, C.P. 44740, Cuba.
Macromolecular Bioscience
|August 22, 2006
Summary
Researchers enhanced Naproxen
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Pharmacology
Background:
- Polysaccharides like mannan and carboxymethylcellulose are biocompatible.
- Cyclodextrins improve drug solubility and bioavailability.
- Naproxen is a widely used non-steroidal anti-inflammatory drug (NSAID).
Purpose of the Study:
- To create novel drug delivery systems by grafting beta-cyclodextrin onto polysaccharides.
- To investigate the formation of supramolecular complexes between these modified polymers and Naproxen.
- To evaluate the impact of these complexes on Naproxen's solubility and anti-inflammatory efficacy.
Main Methods:
- Periodate oxidation of mannan and carboxymethylcellulose.
- Reductive alkylation to graft beta-cyclodextrin derivatives.
- Formation of supramolecular complexes with Naproxen.
- Fluorescence spectroscopy for complex confirmation.
- Solubility and in vivo anti-inflammatory assays.
Main Results:
- Successful grafting of beta-cyclodextrin onto polysaccharides was achieved.
- Supramolecular complex formation between modified polymers and Naproxen was confirmed.
- Naproxen solubility increased 3.8-4.6 fold.
- In vivo anti-inflammatory activity of Naproxen was enhanced 1.7-fold.
Conclusions:
- Beta-cyclodextrin-grafted polysaccharides are effective carriers for Naproxen.
- This approach significantly enhances Naproxen's solubility and anti-inflammatory properties.
- These novel supramolecular complexes show promise for improved NSAID delivery.
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