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[Effect of long-term intake of Y3+ in drinking water on immune function of rats]
Ping Zhang1, Wei-Dong Yang, Jie-Sheng Liu
1Department of Biotechnology, Jinan University, Guangzhou 510632, China.
Objective:
The aim of this paper was to learn the effects of Y3+ on immune function of rats.
Methods:
The rats were fed with water dissolved different level Y3+ (0 mg/L, 0.534 mg/L, 53.4 mg/L, 5340 mg/L) for 6 months. The relative weight of spleen and thymus of F1 rat were calculated, and the functions of cellular immunity and humoral immunity were determined by flow cytometry (FCM) and enzyme-linked immunosorbnent assay (ELISA), respectively.
Results:
The results showed that a significant increase of IgG, IgM were observed in the dosage group of 0.534 mg/L, in 53.4 mg/L, no change was observed. In contrast, a significantly decrease in CD3, CD8, , IgG, IgM and increase in CD4/CD8 were observed in 5340 mg/L group.
Conclusion:
Long-term intake of Y3+ in low level had certain impact on cellular immunity and humoral immunity of rats' offspring.