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[Correlation of light rare earth elements in rats hair, blood and organs]
Qing Xie1, Ou-Yang Li, Xiao-Ming Lin
1School of Public Health, Peking University, Beijing 100083, China.
Objective:
To study the correlation of rare earth elements (REEs) in the rats' hair, blood and organs.
Methods:
Based on the level of animal weights, 50 healthy male SD rats were randomly divided into five groups including control group and four Citrate REEs level groups (low, middle, high-I and high-II). Before the experiment, the hair of rats' back was eliminated. After the rats were fed for four weeks, the fresh hair of the rats was collected. Except the high-II group, the blood and organs of the others were collected. The high-II group was fed for other four weeks without Citrate REEs. At the end of eighth week, hair, blood and organs of the high-II group were collected. Determination of light REEs concentration in the rats' hair, blood, liver, spleen and bone by ICP-MS.
Results:
The correlation coefficients of REEs concentration between hair and organs (such as liver, spleen and bone) were more than 0.5, while those of REEs concentration between blood and organs (such as liver spleen and bond) were less than 0.5. In the group H- Il, the Rees concentration in blood, hair, liver, spleen and bone were all decrease, and the REEs concentration of blood was close to that of the control groups.
Conclusion:
The concentrations of REEs in these organs were different. And hair was better than blood as a biomarker to reflect body exposure of REEs.
