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[Transient left ventricular apical ballooning syndrome or Takotsubo cardiomyopathy. About 11 cases]

R El Mahmoud1, F Leyer, P Michaud

  • 1Service de cardiologie, CHI Le-Raincy-Montfermeil, 10, rue du général-Leclerc, 93370 Montfermeil, France. emrami@yahoo.fr

Annales De Cardiologie Et D'Angeiologie
|August 23, 2006
PubMed

Insights

Takotsubo cardiomyopathy, a condition mimicking heart attacks, presents with chest pain and abnormal ECGs but normal coronary arteries. This syndrome, also known as transient left ventricular apical ballooning, has a good long-term prognosis.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Takotsubo cardiomyopathy is a recently identified clinical entity that mimics ST-elevation myocardial infarction.
  • It is characterized by chest pain, electrocardiographic abnormalities, and elevated cardiac biomarkers in the absence of significant coronary artery stenosis.

Observation:

  • The study included 11 patients suspected of having Takotsubo cardiomyopathy between March 2003 and March 2005.
  • All patients exhibited abnormal electrocardiograms and elevated troponin I levels.
  • Coronary angiography revealed normal coronary arteries, while left ventriculography showed apical regional wall-motion abnormalities with a characteristic ballooning appearance.

Findings:

  • A psychological or physical trigger was identified in 8 out of 11 patients.
  • The mean age of the patients was 70.3 years.
  • All patients experienced an uncomplicated recovery with no recurrence during a mean follow-up of 15 months.

Implications:

  • Takotsubo cardiomyopathy, or transient left ventricular apical ballooning syndrome, carries a favorable long-term prognosis despite potential for severe complications.
  • It should be considered in the differential diagnosis of ST-elevation myocardial infarction, especially in cases with normal coronary arteries.
  • The exact cause of Takotsubo cardiomyopathy remains unknown.

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