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Related Experiment Videos

Gene expression profiling for pharmaceutical safety assessment.

Russell Huby1, Jonathan D Tugwood

  • 1AstraZeneca R&D, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK. Russell.Huby@astrazeneca.com

Expert Opinion on Drug Metabolism & Toxicology
|August 23, 2006
PubMed
Summary

Toxicogenomics uses gene expression profiling in toxicology to predict chemical toxicity. Despite significant investment and groundwork, its impact on drug discovery remains limited, highlighting a gap between theory and practice.

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Area of Science:

  • Toxicology
  • Genomics
  • Pharmacology

Background:

  • Toxicogenomics applies gene expression profiling to toxicology, generating large datasets to understand toxicity mechanisms.
  • It is anticipated to aid in predicting the toxic potential and mechanisms of novel chemical entities for risk assessment.

Purpose of the Study:

  • To assess the successes and shortcomings of toxicogenomics in drug discovery.
  • To explore how toxicogenomics can be effectively applied to the drug discovery pipeline.

Main Methods:

  • Review of existing toxicogenomics methodologies and proof-of-concept studies.
  • Analysis of data generation, database creation, and data analysis tool development in the field.

Main Results:

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  • Significant investment has been made in toxicogenomics by the pharmaceutical industry.
  • There is limited reported evidence of toxicogenomics significantly impacting drug discovery and development.

    • Conclusions:

    • Challenges remain in bridging the gap between toxicogenomics theory and practical application in the pharmaceutical industry.
    • Further efforts are needed to translate toxicogenomic insights into tangible benefits for drug discovery pipelines.