Species variability in cardiovascular research: the example of adrenocorticotrophin-induced hypertension
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Updated: Aug 6, 2026

Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats
Published on: December 5, 2017
Judith A Whitworth1, Yi Zhang, George Mangos
1The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia. director@jcsmr.anu.edu.au
Abstract:
1. Lawrie Beilin has contributed greatly to international hypertension research through both animal and human studies. 2. Animals are used in biomedical research to gain insights that can be extrapolated ultimately to humans. 3. A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species. 4. Caution should be exercised in extrapolating data from animals to humans.
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