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Published on: February 28, 2012
Seasonal variations of ventricular arrhythmia clusters in defibrillator recipients
Thomas Stuber1, Christa Eigenmann, Etienne Delacrétaz
1Swiss Cardiovascular Center Berne, University Hospital, Berne, Switzerland.
Insights
Ventricular arrhythmia clusters in implantable cardioverter-defibrillator recipients occur more often in winter and spring. These findings suggest seasonal variations impact electrical storm events, requiring further investigation into contributing factors.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Devices
Background:
- Clustering ventricular arrhythmias pose management challenges in patients with implantable cardioverter-defibrillators (ICDs).
- Identifying triggers for these arrhythmias is often difficult.
- Previous research indicates seasonal patterns in cardiovascular events.
Purpose of the Study:
- To investigate if seasonal factors influence ventricular electrical instability.
- To determine if seasonality exacerbates arrhythmia clusters and electrical storm in ICD recipients.
Main Methods:
- Follow-up of 214 ICD recipients over 3.3 ± 2.2 years.
- Defined arrhythmia cluster as ≥3 events triggering ICD therapy within 2 weeks.
- Analyzed time intervals between clusters across months and seasons using statistical tests.
Main Results:
- 98 arrhythmia clusters were observed in 51 patients over 698 patient-years.
- Clustering ventricular arrhythmias were significantly more frequent in winter and spring.
- Time intervals between clusters were shortest in winter (16 days) and spring (11.5 days) compared to summer (34.5 days) and fall (50.5 days).
Conclusions:
- Significant seasonal variations exist in the incidence of arrhythmia clusters among ICD recipients.
- The study highlights a link between seasonality and ventricular arrhythmia clustering.
- Further research is needed to explore environmental, activity-related, or psychological factors driving these seasonal variations.
Background:
Clustering ventricular arrhythmias are the consequence of acute ventricular electrical instability and represent a challenge in the management of the growing number of patients with an implantable cardioverter-defibrillator (ICD). Triggering factors can rarely be identified.
Objectives:
Several studies have revealed seasonal variations in the frequency of cardiovascular events and life-threatening arrhythmias, and we sought to establish whether seasonal factors may exacerbate ventricular electrical instability leading to arrhythmia clusters and electrical storm.
Methods:
Two hundred and fourteen consecutive defibrillator recipients were followed-up during 3.3 +/- 2.2 years. Arrhythmia cluster was defined as the occurrence of three or more arrhythmic events triggering appropriate defibrillator therapies within 2 weeks. Time intervals between two clusters were calculated for each month and each season, and were compared using Kruskal-Wallis test and Wilcoxon-Mann-Whitney test with Bonferroni adjustment.
Results:
During a follow-up of 698 patient years, 98 arrhythmia clusters were observed in 51 patients; clustering ventricular arrhythmias were associated with temporal variables; they occurred more frequently in the winter and spring months than during the summer and fall. Accordingly, the time intervals between two clusters were significantly shorter during winter and spring (median and 95% CI): winter 16 (5-19), spring 11.5 (7-25), summer 34.5 (15-55), fall 50.5 (19-65), P = 0.0041.
Conclusion:
There are important seasonal variations in the incidence of arrhythmia clusters in ICD recipients. Whether these variations are related to environmental factors, change in physical activity, or psychological factors requires further study.
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