Related Experiment Video
Updated: Jul 25, 2026

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
Severe hematological side effects following Rituximab therapy in children
Sophie Larrar1, Corinne Guitton, Marjolaine Willems
1Department of pediatrics, Bicêtre hospital, 94 270 Le Kremlin Bicêtre, France.
Abstract:
Rituximab use in severe auto-immune diseases has recently increased. Scattered reports of opportunistic infections were the only reported serious side effects related to rituximab in pediatric patients .Here, we report transient severe acute thrombocytopenia and neutropenia respectively a few days after rituximab infusion in two children with autoimmune haemolytic anaemia. In both cases, cytopenia was reversible in a few days. The occurrence of cytopenias shortly after an infusion and their rapid reversibility suggest that these hematological side-effects were attributable to a direct toxicity of rituximab. Blood cell count must be carefully monitored after rituximab infusion in young children with autoimmune diseases.
Related Concept Videos
Regulation of Hematopoietic Stem Cells
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Pharmacokinetics in Pediatric Patients: Drug Excretion
Hypersensitivity Reactions: Cytolytic Reactions

