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Updated: Aug 6, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
Gaucher disease and multiple myeloma
Régis Costello1, Thérèse O'Callaghan, Gérard Sébahoun
1Département d'Hématologie, Hôpital Nord, Assistance Publique des Hôpitaux de Marseille, Faculté de Médecine de Marseille, Université de la Méditerranée, Marseille, France. regis.costello@free.fr
Abstract:
Gaucher disease (GD) is the most frequent lysosomal storage disease and corresponds to an inherited deficiency of glucocerebrosidase. Due to excessive accumulation of glucocerebroside in bone marrow, both cytopenia and bone lesions may occur. The incidence of malignant disorders has been evoked in non-neuronopathic type I GD. More particularly, many case reports have been published that describe the association between GD and multiple myeloma (MM). Here, we first deal with diagnosis criteria that allow to distinguish between bona fide Gaucher celles and the so-called pseudo or pseudo-pseudo Gaucher cells. We then analyse relevant case reports and recent articles that provide convincing data regarding GD and MM association and suggest physiopathological links between the two disorders.
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