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CSF BACE1 activity is increased in CJD and Alzheimer disease versus [corrected] other dementias
R M D Holsinger1, J S Lee, A Boyd
1University of Melbourne, Parkville, Victoria, 3010, Australia. d.holsinger@fhs.usyd.edu.au
Neurology
|August 23, 2006
Abstract:
To assess the diagnostic utility of CSF BACE1 activity for discriminating Alzheimer disease (AD) from other dementias, particularly Creutzfeldt-Jakob disease (CJD), the authors studied 26 patients with sporadic CJD, 21 patients with AD, and 21 patients with various non-AD, non-CJD dementias (DCs). CSF BACE1 activity was elevated in AD in comparison with DC (p = 0.01). Unexpectedly, CSF BACE1 activity was also increased in sporadic CJD (p = 0.02).
