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[MR perfusion and spectroscopic imaging in WHO grade II astrocytomas]

M-A Weber1, M Vogt-Schaden, O Bossert

  • 1Abteilung Radiologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg. m.a.weber@dkfz.de

Der Radiologe
|August 23, 2006
PubMed
Abstract

Insights

Magnetic Resonance Imaging (MRI) techniques can identify early signs of anaplasia in WHO grade II astrocytomas. This allows for earlier prognosis prediction compared to conventional MRI.

Area of Science:

  • Neuro-oncology
  • Medical Imaging
  • Biomarkers

Background:

  • WHO grade II astrocytomas are challenging to assess for anaplastic transformation using conventional MRI.
  • Early detection of anaplastic areas is crucial for accurate prognosis and treatment planning.

Purpose of the Study:

  • To evaluate if MR perfusion imaging and MR spectroscopic imaging (MRSI) can detect anaplastic areas in WHO grade II astrocytomas.
  • To determine if these anaplastic areas are co-localized.
  • To assess the potential for improved prognosis prediction using these advanced MRI techniques.

Main Methods:

  • Fifteen patients with WHO grade II astrocytomas underwent regular MR perfusion imaging and MRSI.
  • Regional cerebral blood volume (rrCBV) and blood flow (rrCBF) were measured using MR perfusion.
  • Choline/creatine (Cho/Cr) and choline/N-acetyl-aspartate (Cho/NAA) ratios were quantified using MRSI.

Main Results:

  • Progressing astrocytomas showed significantly higher rrCBF and rrCBV at initial examination compared to stable tumors.
  • While not statistically significant, progressing tumors also exhibited higher Cho/NAA and Cho/Cr ratios.
  • Areas of maximal perfusion and maximal metabolic ratios (Cho/NAA, Cho/Cr) were co-localized in progressing tumors and later showed contrast-enhancement.

Conclusions:

  • MR perfusion imaging can identify anaplastic areas in WHO grade II astrocytomas earlier than conventional MRI.
  • The findings suggest that MR perfusion imaging aids in earlier and more accurate prognosis prediction for these tumors.

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