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[Endothelial dysfunction in patients with scleroderma systemic].

N A Karoli, E E Orlova, A P Rebrov

    Klinicheskaia Meditsina
    |August 24, 2006
    PubMed
    Summary
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    Scleroderma patients show endothelial lesions and impaired vascular wall functions. This study highlights significant endothelial dysfunction and reduced antithrombogenic activity in scleroderma systematica (SS).

    Area of Science:

    • Vascular Biology
    • Rheumatology
    • Endothelial Function

    Background:

    • Scleroderma systematica (SS) is a connective tissue disease.
    • Endothelial dysfunction is implicated in the pathogenesis of SS.
    • Understanding vascular wall function is crucial for SS management.

    Purpose of the Study:

    • To investigate endothelial lesions in SS patients.
    • To assess disturbances in antithrombogenic and vasoregulative functions of the vascular wall.
    • To evaluate endothelial function and circulating endotheliocytes in SS.

    Main Methods:

    • Reactive hyperemia and nitroglycerin tests for vasomotor endothelial function.
    • Cuff test for antithrombogenic (anticoagulative and fibrinolytic) activity.
    • Measurement of circulating endotheliocytes (desquamated endotheliocytes).

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    Main Results:

    • Tendency towards brachial artery narrowing and hypertrophy in SS patients.
    • Impaired endothelium-dependent vasodilatation observed in 28.6% of SS patients.
    • Significant increase in circulating endotheliocytes, indicating endothelial lesion.
    • Significant decrease in fibrinolytic and anticoagulative activity in SS patients compared to controls.

    Conclusions:

    • SS patients exhibit endothelial lesions.
    • Disturbances in vasoregulative and antithrombogenic vascular wall activity are present in SS.
    • Findings suggest a significant role of endothelial dysfunction in the pathophysiology of SS.