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Long-term prognosis and factors affecting biliary atresia from experience over a 25 year period
Hong-Shiee Lai1, Wei-Jao Chen, Chiu-Ching Chen
1Department of Surgery, National Taiwan University Hospital, Taipei. hslai@ha.mc.ntu.edu.tw
Insights
Early Kasai
Area of Science:
- Pediatric Surgery
- Hepatology
Background:
- Biliary atresia (BA) is a serious neonatal liver disease.
- Kasai's operation is a common surgical procedure for BA.
- Long-term outcomes after Kasai's operation require further investigation.
Purpose of the Study:
- To evaluate the long-term prognosis of biliary atresia (BA) patients.
- To identify factors influencing outcomes after Kasai's operation.
Main Methods:
- Retrospective study of 141 BA patients who underwent Kasai's operation (1976-2000).
- Analysis of factors including age at surgery, bile flow, cholangitis, antibiotic use, and cyst formation.
- Survival rates, jaundice-free status, and complication frequencies were assessed.
Main Results:
- 5-year and 10-year native liver survival rates were 34.8% and 30.5%.
- Surgery before 60 days improved outcomes (44.8% 5-year survival).
- Good bile flow (81.6%), jaundice-free status (62.4%), and prophylactic antibiotics reduced cholangitis.
Conclusions:
- Early Kasai's operation (before 60 days) improves long-term survival.
- Achieving good bile flow and preventing cholangitis are critical.
- Long-term prophylactic antibiotics and avoiding intrahepatic cysts positively impact prognosis.
Background:
The purpose of this study was to delineate the long-term prognosis and factors we have noted in our 25 years of experience treating patients suffering from biliary atresia (BA) who have undergone Kasai's operation.
Methods:
We studied 141 patients (69 male and 72 female infants) who underwent Kasai's operation at the National Taiwan University Hospital between 1976 and 2000. Factors analyzed included age at time of surgery, postoperative bile flow, frequency of cholangitis, prophylactic long-term oral antibiotics given, and intrahepatic biliary cyst formation.
Results:
The 5-year and 10-year survival rates for native liver patients were 34.8% (49/141) and 30.5% (43/141). If surgery was performed before the patient was 60 days old, the results were 44.8% (26/58) and 39.7% (23/58). Good bile flow occurred in 115 patients (81.6%) and 88 (62.4%) became jaundice-free. Cholangitis was encountered in 77 patients (54.6%) within the first two postoperative years. Prophylactic oral antibiotics lowered the rate of recurrent cholangitis (p = 0.011). Multiple intrahepatic biliary cysts occurred in 11.3% (16/141) of patients, who had a higher mortality rate when compared with the other patients (p = 0.037). The factors that had a positive effect include: (1) less than 60 days of age at time of surgery, (2) good bile flow, (3) low frequency of cholangitis, (4) long-term prophylactic antibiotics, and (5) no multiple intrahepatic cyst formation.
Conclusion:
The long-term survival rate can be improved if Kasai's operation is performed early, there is a detailed dissection producing good bile flow, and long-term prophylactic antibiotics are given to prevent recurrent cholangitis and formation of multiple intrahepatic cysts.