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Accelerated satiation after duodenal switch.

Picard Marceau¹, Michel Cabanac, Patrick C Frankham

¹Department of Surgery, Laval University, Quebec, Canada. picard.marceau@chg.ulaval.ca

Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery

|August 24, 2006

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This study introduces negative alliesthesia (NA) testing to measure satiation after bariatric surgery. Post-duodenal switch surgery significantly accelerated NA and satiety times, indicating altered food perception.

Area of Science:

Bariatric Surgery
Gastroenterology
Clinical Physiology

Background:

Introduces negative alliesthesia (NA), a physiological test for satiation, into clinical bariatric surgery practice.
NA measures the point at which repeated pleasant taste stimuli become unpleasant due to satiation.
This test has not been previously applied in a clinical setting.

Purpose of the Study:

To evaluate the utility of the negative alliesthesia test in assessing satiation after bariatric surgery.
To measure changes in negative alliesthesia and satiety times following duodenal switch procedures.
To assess hedonic ratings of sweet stimuli in patients undergoing bariatric surgery.

Main Methods:

Measured time to negative alliesthesia (NA) and satiety with repeated sweet stimulus ingestion.

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Assessed hedonic ratings of the sweet stimulus.

Tested 9 patients pre- and post-duodenal switch (3 and 6 months) and 10 morbidly obese patients.

Main Results:

Negative alliesthesia and satiety occurred significantly faster after duodenal switch surgery.
NA time decreased from 16.0 to 5.7 minutes (P < 0.0004).
Satiety time decreased from 26.7 to 10.7 minutes (P < 0.001); hedonic ratings showed a decreasing trend post-surgery.

Conclusions:

Duodenal switch surgery significantly modifies negative alliesthesia.
The negative alliesthesia test shows potential for clinical application in bariatric surgery due to its simplicity and ingenuity.