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Periprosthetic osteolysis and its association with RANKL expression.

D Veigl¹, J Niederlová, O Kryštůfková

¹Department of Orthopedics, First Faculty of Medicine, Charles University, Prague, Czech Republic. veigl@iol.cz

Physiological Research

|August 24, 2006

Summary

Extensive osteolysis around hip implants is linked to wear particles. This study found receptor activator of nuclear factor kappa B ligand (RANKL) in tissues with significant wear, particularly with loosened cemented implants.

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Area of Science:

Orthopedic Surgery
Biomaterials Science
Immunology

Background:

Periprosthetic osteolysis, bone loss near implants, is a major cause of orthopedic implant failure.
The RANKL/RANK/OPG system is implicated in osteolysis, but its direct correlation with wear particles and clinical presentation needs further investigation.

Purpose of the Study:

To investigate the relationship between the extent of osteolysis, wear particle load, and the expression of receptor activator of nuclear factor kappa B ligand (RANKL) in tissues surrounding aseptically loosened hip replacements.

Main Methods:

Analysis of periprosthetic tissues from 59 patients undergoing revision hip surgery for aseptic loosening.
Histological examination to assess wear particle presence and RANKL-positive cells.

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Last Updated: Jul 20, 2026

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation

Published on: March 15, 2018

Main Results:

Receptor activator of nuclear factor kappa B ligand (RANKL)-positive cells were identified in 23 out of 59 patients.
RANKL expression was predominantly observed in tissues with substantial wear debris and associated with loosened cemented implants.

Conclusions:

The presence of receptor activator of nuclear factor kappa B ligand (RANKL) in periprosthetic tissues correlates with significant wear debris.
RANKL may play a role in the osteolysis associated with aseptically loosened cemented hip implants.