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Radiation sensitization by an iodine-labelled DNA ligand
R F Martin1, V Murray, G D'Cunha
1Molecular Sciences Group, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia.
International Journal of Radiation Biology
|May 1, 1990
Abstract:
An iodinated DNA ligand, iodo Hoechst 33258, which binds in the minor groove of DNA, enhances DNA strand breakage and cell killing by UV-A irradiation. The sites of UV-induced strand breaks reflect the known sequence specificity of the ligand.