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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Updated: Jan 27, 2026

Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia
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Leukemia stem cells.

Ling Luo1, Zhong Chao Han

  • 1State Key Laboratory of Experimental Hematology, National Research Center for Stem Cell Engineering, Technology, Institute of Hematology, Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin.

International Journal of Hematology
|August 24, 2006
PubMed
Summary
This summary is machine-generated.

Cancer stem cells drive leukemia growth and maintenance. Research on leukemia stem cells (LSCs) provides critical insights into cancer pathology and developing targeted therapies.

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Area of Science:

  • Oncology
  • Stem Cell Biology
  • Hematology

Background:

  • Cancer is characterized by uncontrolled cell proliferation.
  • Cancer stem cells (CSCs) are a subpopulation of tumor cells responsible for cancer initiation and maintenance.
  • Leukemia research has provided the most advanced understanding of CSC biology.

Purpose of the Study:

  • To review the biological characteristics of leukemia stem cells (LSCs).
  • To highlight insights into leukemogenic pathology derived from LSC research.
  • To discuss the potential for LSC-targeted therapies.

Main Methods:

  • Review of existing scientific literature on leukemia stem cells.
  • Focus on biological characterization of LSCs across different leukemia types.
  • Analysis of LSC properties, including self-renewal and repopulation capabilities.

Main Results:

  • Leukemia stem cells (LSCs) have been conclusively identified and characterized.
  • LSCs possess self-renewal properties and are crucial for cancer initiation.
  • LSC research offers key insights into the pathology of leukemia.
  • Studies involving NOD/SCID mice have validated the role of LSCs.

Conclusions:

  • Leukemia stem cells are fundamental to understanding and treating leukemia.
  • Targeting LSCs represents a promising therapeutic strategy.
  • Further research into LSC biology will advance cancer treatment modalities.