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Circulating soluble receptor for advanced glycation end products is inversely associated with glycemic control and

Giuseppina Basta1, Anna Maria Sironi, Guido Lazzerini

  • 1Consiglio Nazionale delle Richerche Institute of Clinical Physiology, Via Moruzzi, 1, 56124 Pisa, Italy. lapina@ifc.cnr.it

The Journal of Clinical Endocrinology and Metabolism
|August 24, 2006
PubMed
Abstract

Insights

Plasma soluble RAGE (sRAGE) is lower in type 2 diabetes patients, linked to higher blood sugar and inflammation. S100A12 protein, not CML, is associated with reduced sRAGE levels in hyperglycemia.

Area of Science:

  • Endocrinology
  • Vascular Biology
  • Metabolic Syndrome

Background:

  • Advanced glycation end products (AGEs) and their receptor (RAGE) interaction contribute to diabetic vascular complications.
  • Soluble RAGE (sRAGE) may protect against cardiovascular disease by neutralizing AGEs.

Purpose of the Study:

  • To investigate the association between plasma sRAGE levels and glycemic control, inflammation, and RAGE ligands (CML, S100A12).

Main Methods:

  • Study included 160 subjects: 84 with type 2 diabetes and 76 controls.
  • Measured plasma sRAGE, CML, S100A12, hemoglobin A1c, insulin resistance, C-reactive protein, and cardiovascular disease risk scores.

Main Results:

  • Diabetic patients had significantly lower plasma sRAGE and higher CML levels than controls.
  • Hemoglobin A1c, insulin resistance, and C-reactive protein were independently associated with lower sRAGE.
  • In a subgroup analysis, plasma S100A12 was the sole determinant of plasma sRAGE, and higher S100A12 correlated with increased cardiovascular disease risk.

Conclusions:

  • Plasma sRAGE is down-regulated in chronic hyperglycemia.
  • S100A12 protein, a ligand of RAGE, is associated with reduced sRAGE levels in hyperglycemia, unlike CML.

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