Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Suspected Scaphoid Fractures Investigated with Limited Sequence Wrist MRI Scans: A Prospective Cohort Study.

The journal of hand surgery Asian-Pacific volume·2025
Same author

Aging in place or aging out of place? Family caregivers' perspectives on care for older Pakistani migrants in Norway.

European journal of ageing·2024
Same author

The Morality of Care: Female Family Caregivers' Motivations for Providing Care to Older Migrants.

Qualitative health research·2024
Same author

Intergenerational ambivalence among families with a migrant background caring for older relatives.

Journal of migration and health·2024
Same author

Re-irradiation for recurrent/progressive pediatric brain tumors: from radiobiology to clinical outcomes.

Expert review of anticancer therapy·2023
Same author

Changing dynamics of caregiving: a meta-ethnography study of informal caregivers' experiences with older immigrant family members in Europe.

BMC health services research·2023

Related Experiment Video

Updated: Jul 20, 2026

Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids
05:39

Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids

Published on: April 5, 2024

Does the tumor microenvironment influence radiation-induced apoptosis?

Alistair Hunter1, Andre Hendrikse, Michael Renan

  • 1Radiation Oncology, Department of Radiation Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, Cape Town, South Africa. Alistair@curie.uct.ac.za

Apoptosis : an International Journal on Programmed Cell Death
|August 24, 2006
PubMed
Summary

Tumor microenvironment factors like hypoxia, low glucose, and acidosis can inhibit radiation-induced apoptosis, potentially reducing radiotherapy effectiveness. Understanding these factors is crucial for improving cancer treatment outcomes.

More Related Videos

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:04

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Related Experiment Videos

Last Updated: Jul 20, 2026

Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids
05:39

Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids

Published on: April 5, 2024

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:04

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Area of Science:

  • Oncology
  • Cell Biology
  • Radiotherapy Research

Background:

  • Cytotoxic anti-cancer agents induce apoptosis in both tumor and normal tissues.
  • Tumor microenvironment conditions, including hypoxia, low glucose, and acidosis, can significantly impact treatment efficacy.
  • Apoptosis regulation is critical for determining the therapeutic gain of anti-cancer treatments.

Purpose of the Study:

  • To investigate factors influencing radiation-induced apoptosis in tumors.
  • To understand the impact of tumor microenvironment on apoptotic processes.
  • To determine how hypoxia, low glucose, and acidosis affect radiotherapy outcomes.

Main Methods:

  • Review of existing literature on apoptosis and tumor microenvironment.
  • Analysis of mechanisms by which hypoxia, low glucose, and acidosis modulate apoptosis.
  • Examination of the role of different apoptotic pathways (mitochondrial, SAPK, Fas).

Main Results:

  • Hypoxia can inhibit or modulate radiation-induced apoptosis depending on cell type and timing.
  • Low glucose and energy depletion impair key stages of apoptosis.
  • Acidosis interferes with radiation-induced apoptosis, potentially through cell cycle arrest.

Conclusions:

  • Hypoxia, low glucose, and acidosis are identified as key factors influencing radiation-induced apoptosis.
  • These tumor microenvironment conditions can be detrimental to the effectiveness of radiotherapy.
  • Further research into these factors may lead to improved therapeutic strategies.