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Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
4-difluoro-substituted phenl-5-oxohexahydroquinoline derivatives and their effects on calcium channels
Rahime Simşek1, Miyase Gözde Gündüz, Başar Sirmagül
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey. rsimsek@hacettepe.edu.tr
Abstract:
Twenty new methyl(ethyl) 2,6,6- or 2,7,7-trimethyl-5-oxo-4-(disubstituted phenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates and ten new N,N-diethyl-2,6,6- or 2,7,7-trimethyl-5-oxo-4-(disubstituted phenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide derivatives have been synthesised and screened for their calcium channel antagonistic activity. The compounds were synthesised by the Hantzsch reaction. Calcium antagonistic activities of the compounds were determined by the tests performed on isolated rat ileum and rat thoracic artery.
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