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Updated: Aug 19, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
[Long-term use of narcotics in pain therapy]
1Städtisches Gesundheitsamt Augsburg, Universität Karlsruhe.
Abstract:
From 1. 1. 1976 to 30. 6. 1987, a total of 25,611 prescriptions for narcotics were obtained from pharmacies by 4131 persons living in a town of 250,000 inhabitants in the Federal Republic of Germany. 2412 patients (58.4%) had been prescribed narcotics on only one occasion, 3178 patients (76.9%) over a limited period of six months, presumably for acute pain. Only 520 patients (12.6%) received, over a period of at least six months, five or more narcotic prescriptions per six months. Reasons for the latter prescriptions were malignant tumours in 273 (6.6%) and chronic pain due to benign diseases in 144 (3.5%). In 21 patients (0.5%) the narcotic dosage had risen over two years, presumably because of the development of tolerance. 19 patients had been on narcotics for at least eight years, without their doctor diagnosing addiction. The data suggest that, in prescribing narcotics for patients with incurable disease, the risk of addiction should play no role.
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