Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Redox-triggered interconversion between piperidine chair conformations in a Cu(I/II) complex.

Jing Zhang1, James W Canary

  • 1Department of Chemistry, New York University, New York, NY 10003, USA.

Organic Letters
|August 25, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blunt-force assembly of programmable DNA architectures using π-π stacking.

Nature communications·2026
Same author

DNA Glass: Encasing Diffraction-Quality, Mesoporous DNA Crystals in Architected Silica.

Angewandte Chemie (International ed. in English)·2025
Same author

US must support chemistry research.

Science (New York, N.Y.)·2025
Same author

Transmetalation for DNA-Based Molecular Electronics.

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

Synthesis of Nanographene-DNA Conjugates and Their Profiling with MoS<sub>2</sub> Nanopores.

Nano letters·2025
Same author

Control of Solid-Supported Intra- vs Interstrand Stille Coupling Reactions for Synthesis of DNA-Oligophenylene Conjugates.

Bioconjugate chemistry·2024

This study demonstrates a redox-induced conformational change in a copper-coordinated piperidine ligand. The ligand

Area of Science:

  • Coordination Chemistry
  • Organic Chemistry
  • Spectroscopy

Background:

  • Tripodal ligands are crucial in coordination chemistry for stabilizing metal ions.
  • Piperidine-based ligands offer unique structural and electronic properties.
  • Understanding ligand conformational changes is key to designing novel metal complexes.

Purpose of the Study:

  • To investigate the redox-induced conformational interconversion of a copper-coordinated trans-piperidine tripodal ligand.
  • To elucidate the distinct coordination modes of the ligand in different copper oxidation states.

Main Methods:

  • Exciton-coupled circular dichroism (ECCD) spectroscopy for chiral analysis.
  • Two-dimensional Nuclear Magnetic Resonance (2D NMR) for structural elucidation.

Related Experiment Videos

  • Synthesis and characterization of copper complexes.

    • Main Results:

    • Demonstrated a six-membered ring chair-chair conformational interconversion triggered by redox changes.
    • Identified that in the Cu(I) state, two equatorial groups ligate the copper, leaving one axial group dissociated.
    • Observed that in the Cu(II) state, all three ligand groups (two axial, one equatorial) ligate the copper.

    Conclusions:

    • The copper oxidation state dictates the ligand's coordination geometry and conformational state.
    • Redox stimuli can reversibly alter the ligand's binding mode and the complex's conformation.
    • ECCD and 2D NMR are effective tools for characterizing such dynamic systems.