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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
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Highly enantioselective direct aldol reaction catalyzed by organic molecules

Monika Raj1, Vishnumaya Vishnumaya, Sandeep K Ginotra

  • 1Department of Chemistry, Indian Institute of Technology, Kanpur, India 208 016.

Organic Letters
|August 25, 2006
PubMed

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The aldol reaction of a ketone under acidic conditions successfully forms an unsaturated carbonyl as the final product instead of an aldol. The acid-catalyzed aldol reaction is depicted in Figure 1.
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This lesson delves into the aldol condensation catalyzed by bases, where aldols undergo dehydration to enals. As shown in Figure 1, the β-hydroxy aldehyde formed in a base-catalyzed aldol addition reaction dehydrates on heating to yield an unsaturated carbonyl product, which is commonly referred to as an enal.
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