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Updated: Jul 20, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
Intralesional therapy of metastatic spreading melanoma with beta-interferon
Harriet Rapprich1, Manfred Hagedorn
1Department of Dermatology, Klinikum Darmstadt, Darmstadt, Germany. stefan.rapprich@klinikum-darmstadt.de
Abstract:
A 74-year-old female patient developed multiple local metastases after excision of a nodular melanoma of the left cheek. There was no regression after treatment with dacarbazine (DTIC) and radiotherapy. After treatment with intralesional interferon-beta, the metastases regressed completely. The dosage was 5 million IU interferon-beta (Fiblaferon) three times weekly with courses of two and four weeks, separated by a month. Except for local swelling and inflammation, no side effects occurred. Five years after completing therapy, the patient is still tumor-free.
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