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Updated: Jul 20, 2026

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
Published on: July 16, 2020
The role of electrostatics in protein-membrane interactions
Anna Mulgrew-Nesbitt1, Karthikeyan Diraviyam, Jiyao Wang
1Weill Medical College of Cornell University, New York, NY 10021, USA.
Abstract:
Many experimental, structural and computational studies have established the importance of nonspecific electrostatics as a driving force for peripheral membrane association. Here we focus on this component of protein/membrane interactions by using examples ranging from phosphoinositide signaling to retroviral assembly. We stress the utility of the collaboration of experiment and theory in identifying and quantifying the role of electrostatics not only in contributing to membrane association, but also in affecting subcellular targeting, in the control of membrane binding, and in the organization of proteins and lipids at membrane surfaces.
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