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Updated: Jul 20, 2026

Induction of Cerebral Arterial Gas Embolism in Rat
Published on: October 18, 2024
Cerebral air embolism after intrathoracic anti-cancer drug administration
Yoshinori Yamashita1, Hidenori Mukaida, Naoki Hirabayashi
1Department of Surgery, Hiroshima City Asa Hospital, Hiroshima, Japan. yosy.811kob@k3.dion.ne.jp
Abstract:
We report a case of cerebral arterial air embolism that was followed by a brain computed tomographic scan and magnetic resonance imaging during the first week after onset. A 73-year-old man was admitted for treatment of pleural dissemination that was a recurrence after right lower bilectomy for advanced lung cancer. Thirty minutes after an anti-drug administration through the chest drainage tube, he lost consciousness shortly after coughing. A bubble in the inferior sagittal sinus was observed on the day of the stroke, which then disappeared within 24 hours. It seems that the anti-cancer agent evoked inflammation at the visceral pleura and the subject inhaled massive air flow into the systemic circulation.
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