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Published on: March 5, 2020
Effects of ad hoc clopidogrel loading versus pre-treatment on P-selectin expression after coronary stent implantation
Tibor Szük1, Béla Nagy, Zsuzsanna Bereczky
1Institute of Cardiology, Debrecen, Hungary.
Abstract:
Stents represent a thrombogenic surface where one of the earliest events is the deposition of platelets. Activated platelets express neoepitopes that enable them to form homo- and heterotypic aggregates and activate the coagulation system. In this study, we investigated the effects of ad hoc clopidogrel treatment compared to a clopidogrel pretreated group on platelet P-selectin expression. We found that after stent implantation in the ad hoc treated group, P-selectin expression decreased after 1 h, while the initial decrease in platelet count normalized after 4 h. Aspirin non-responsiveness did not influence the results. These data point to the beneficial effect of clopidogrel treatment in reducing platelet reactivity during stenting.
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