Related Experiment Video
Updated: Jul 20, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
Published on: April 4, 2025
Chronic renal failure with severe mesangiolysis in a hematopoietic stem cell transplant recipient
Hiroshi Nishi1, Chie Tomida, Michihiro Gotoh
1Department of Internal Medicine, Hitachi General Hospital, Hitachi, Ibaraki, Japan. hrnishi-tky@umin.ac.jp
Abstract:
Chronic progressive renal failure is a well-recognized complication in hematopoietic stem cell transplantation (HSCT) recipients. Although thrombotic microangiopathy or chemotherapeutic agents are frequently associated, total body irradiation might also be one of the suspected etiologic factors. This study describes a 38-year-old female patient with acute lymphoblastic leukemia treated with HSCT who developed chronic renal dysfunction after transplantation. Renal biopsy revealed focal and diffuse glomerulosclerosis with extensive mesangiolytic lesions. Her clinical course implied that pretransplant irradiation might have the most impact on the expression of this glomerular lesion.
Related Concept Videos
Kidney Transplant II: Surgical Procedure
Kidney Transplant I: Introduction
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Chronic Kidney Disease II: Clinical Manifestations
Diabetic Nephropathy
Kidney Transplant III: Nursing Management

