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Related Experiment Videos

Sparse odor coding in awake behaving mice.

Dmitry Rinberg1, Alex Koulakov, Alan Gelperin

  • 1Monell Chemical Senses Center, Philadelphia, Pennsylvania, 19104, USA. rinbergd@janelia.hhmi.org

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|August 25, 2006
PubMed
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Odor processing in the olfactory bulb differs between awake and anesthetized mice. Mitral cell responses to odors are less frequent and weaker in awake mice, suggesting a sparser odor representation.

Area of Science:

  • Neuroscience
  • Olfactory system research

Background:

  • Mitral cells in the olfactory bulb are key to initial odor processing.
  • Most mitral cell activity data comes from anesthetized animal studies.

Purpose of the Study:

  • To compare olfactory mitral cell responses in awake versus anesthetized mice.
  • To investigate how anesthesia affects odor representation in the olfactory bulb.

Main Methods:

  • Recorded and compared odor-elicited firing rate changes in mitral cells.
  • Utilized awake behaving mice and anesthetized mice models.

Main Results:

  • Odor responses in mitral cells were larger and more frequent in anesthetized mice.
  • Only 27% of odor-responsive mitral cells in anesthesia remained responsive when awake.

Related Experiment Videos

  • Awake responses were smaller in amplitude, with some changing sign.

    • Conclusions:

    • Odor representation in the olfactory bulb is sparser in awake mice compared to anesthetized preparations.
    • Anesthesia significantly alters mitral cell odor processing and representation.