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Related Experiment Videos

Augmentation of coronary flow improves myocardial function in exercise.

P A Gwirtz1, J M Dodd-o, M A Brandt

  • 1Department of Physiology, Texas College of Osteopathic Medicine, Fort Worth 76107-2690.

Journal of Cardiovascular Pharmacology
|May 1, 1990
PubMed
Summary

Increasing coronary blood flow through vasodilation during exercise enhances myocardial contractile function. This suggests that cardiac function can be limited by blood flow during strenuous activity.

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Area of Science:

  • Cardiovascular Physiology
  • Exercise Physiology

Background:

  • Myocardial contractile function is crucial for adequate cardiac output during exercise.
  • The relationship between coronary blood flow and myocardial performance under exercise conditions requires further elucidation.

Purpose of the Study:

  • To investigate whether myocardial contractile function is flow-limited during submaximal exercise.
  • To determine the effects of enhanced coronary blood flow on cardiac performance during exercise.

Main Methods:

  • Six chronically instrumented dogs were subjected to submaximal exercise.
  • Coronary blood flow (CBF), left ventricular pressure (LVP), and myocardial segment length (SL) were measured.
  • Effects of alpha 1-adrenergic blockade (prazosin) and direct vasodilation (adenosine) on CBF and cardiac function were assessed during exercise.

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Main Results:

  • Exercise significantly increased CBF, dP/dtmax, and dL/dtmax.
  • Prazosin and adenosine administration during exercise further increased CBF by 22% and 26%, respectively.
  • These increases in CBF led to significant improvements in dP/dtmax and dL/dtmax compared to exercise alone.

Conclusions:

  • Myocardial contractile function may be flow-limited during submaximal exercise.
  • Coronary vasodilation, achieved through alpha 1-adrenergic blockade or direct vasodilators, enhances myocardial contractile function during exercise.