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Alpha-2-macroglobulin is not synthesized by human urothelial cell lines in vitro
M Grófová1, J Bízik, A Lizonová
1Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Neoplasma
|January 1, 1990
Abstract:
We have analyzed 14 human urothelial cell lines in two different transformation grades for the production of a tumor-associated-alpha-2-macroglobulin. It has been shown in radioimmunoprecipitation and immunoblotting tests that human urothelial cells in vitro do not synthesize the wide-spectrum proteinase inhibitor alpha-2-macroglobulin. Four of the tested cell lines were additionally tested for the expression of specific mRNA which resulted in negative findings. The significance of the absence of alpha-2-macroglobulin in the human urothelial cells is discussed.