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[Relationship between the expression of estrogen and progestogen receptors in distant metastasis of nasopharyngeal
Ligen Mo1, Guoqian Kuang, Yuan Luo
1Department of Head and Neck Surgery, the Affiliated Cancer Hospital of Guangxi Medical University, Nanning, 530021, China. ligenmo@163.com
Objective:
To explore the relationship between the expression of estrogen and progestogen receptors (ER/PR) in distant metastasis of nasopharyngeal carcinoma (NPC).
Method:
The expression of ER/PR were detected with immunohistochemical SP method in 81 nasopharyngeal carcinoma who had been treated and followed-up.
Result:
(1) The positive rates of ER and PR in the tissue of NPC were 35.8% and 53.1%. (2) The expression intensity of PR in T stage has obvious statistically significance (P < 0.01), the expression intensity and positive rates of ER in IVb stage were obviously higher than the other stage (P < 0.01). (3) The positive rates of ER and PR in patients of the distant metastasis group (including the distant metastasis found before and after radiotherapy) were obviously higher than the group who have been alive with no evidence of disease for five or more than five years after radiotherapy (P < 0.01) and P < 0.05).
Conclusion:
The positive expression of ER and PR in NPC were well correlated with the distant metastasis, and it increased gradually. Positive expression, especially the strong positive expression points out the bad prognosis. Endocrine treat may reduce and postpone the distant metastasis.
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