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Related Experiment Videos

Interaction between theophylline and mexiletine.

K Ueno1, K Miyai, T Seki

  • 1National Sengokuso Hospital, Osaka, Japan.

DICP : the Annals of Pharmacotherapy
|May 1, 1990
PubMed
Summary

Mexiletine significantly increases theophylline levels in patients with asthma and heart conditions. Careful monitoring and dose adjustments are crucial when these drugs are used together to prevent toxicity.

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Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Drug Interactions

Background:

  • Theophylline is a common medication for asthma and other respiratory conditions.
  • Hepatic microsomal enzymes play a key role in drug metabolism.
  • Mexiletine is an antiarrhythmic drug that can influence these enzymes.

Observation:

  • Three patients with asthma and premature ventricular contractions were on theophylline therapy.
  • Coadministration of mexiletine led to a significant increase in theophylline serum concentrations.
  • One patient experienced nausea and anorexia due to elevated theophylline levels.

Findings:

  • Mexiletine approximately doubled theophylline serum concentrations in the studied patients.
  • Mexiletine serum concentrations remained stable, indicating a specific effect on theophylline metabolism.
  • Theophylline elimination is notably affected by mexiletine coadministration.

Implications:

  • Lower doses of theophylline may be necessary when used concurrently with mexiletine.
  • Close monitoring of theophylline serum concentrations is essential during combined therapy.
  • This interaction highlights the importance of considering drug metabolism when prescribing multiple medications.

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