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Related Experiment Videos

[Seborrheic keratoses. Intact epidermal differentiation despite disordered morphogenesis].

U Wollina1, B Knopf, R Klinger

  • 1Klinik und Poliklinik für Hautkrankheiten, Bereichs Medizin der Friedrich-Schiller-Universität Jena.

Zeitschrift Fur Hautkrankheiten
|February 1, 1990
PubMed
Summary

Seborrheic keratoses, a common skin tumor, show normal epidermal differentiation despite structural changes. This suggests that interactions between the epidermis and dermis play a key role in their development.

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Area of Science:

  • Dermatology
  • Oncology
  • Biochemistry

Context:

  • Seborrheic keratoses are the most common epithelial tumors in adults.
  • Understanding their pathogenesis requires investigating epidermal differentiation and proliferation.
  • Histo- and biochemical techniques are crucial for this analysis.

Purpose:

  • To define the epidermal differentiation and proliferation of seborrheic keratoses.
  • To evaluate specific markers including cytokeratins, zinc-binding proteins, insulin receptors, tissue plasminogen activator (tPA), and calmodulin.

Summary:

  • Immunohistochemical analysis revealed decreased tissue plasminogen activator (tPA) expression in seborrheic keratoses.
  • Epidermal calmodulin concentration was found to be doubled in these tumors.

Related Experiment Videos

  • Differentiation markers showed no significant deviation from normal skin, indicating normal epidermal differentiation.

    • Impact:

    • Seborrheic keratoses exhibit normal epidermal differentiation despite morphogenic alterations.
    • Pathogenesis likely involves complex epidermaldermal interactions.
    • Findings contribute to understanding the biology of this common skin neoplasm.