Related Experiment Video

Updated: Jul 20, 2026

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

MRI evidence of bilateral hippocampal sclerosis in amnestic mild cognitive impairment

M Sepe-Monti1, A De Carolis, G Bomboi

  • 1Neurology, S. Andrea Hospital, University of Rome La Sapienza, Rome, Italy. micaela.sepe_monti@uniroma1.it

European Journal of Neurology
|August 26, 2006
PubMed

Insights

Amnestic mild cognitive impairment (aMCI) can present with bilateral hippocampal sclerosis, as seen on MRI. Coronal T2-weighted MRI images are useful for diagnosing this heterogeneous dementia syndrome.

Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Mild cognitive impairment (MCI) is a transitional stage between normal aging and dementia.
  • Amnestic MCI (aMCI) specifically affects memory and is a common predromal stage for Alzheimer's disease.
  • The underlying neuropathology of aMCI is recognized as heterogeneous, complicating diagnosis and prognosis.

Observation:

  • A case study of a male patient diagnosed with aMCI is presented.
  • Magnetic resonance imaging (MRI) revealed bilateral hippocampal sclerosis in the patient.
  • Hippocampal sclerosis, typically associated with temporal lobe epilepsy, was observed in an aMCI patient.

Findings:

  • The findings suggest that aMCI is not a monolithic condition but a heterogeneous syndrome.
  • Bilateral hippocampal sclerosis can be a presenting feature of aMCI.
  • Coronal T2-weighted MRI sequences effectively visualized the hippocampal pathology.

Implications:

  • Routine dementia workup should consider the utility of coronal T2-weighted MRI images.
  • Identifying specific neuroimaging markers like hippocampal sclerosis may aid in subtyping aMCI.
  • Further research is warranted to explore the spectrum of neuroimaging findings in aMCI and their clinical significance.

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...