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Polyribonucleotide-anthraquinone interactions: in vitro antiviral activity studies
J M Jamison1, K Krabill, D G Flowers
1Department of Chemistry, Kent State University, Ohio 44242.
Cell Biology International Reports
|March 1, 1990
Summary
Certain anthraquinones (AQ) significantly boost the antiviral effects of poly r(A-U) without increasing interferon levels. This discovery offers new avenues for developing potent antiviral therapies.
Area of Science:
- Virology
- Immunology
- Pharmacology
Background:
- Polyribo-adenylic-uridylic acid (poly r(A-U)) is known for its antiviral properties.
- Anthraquinones (AQ) are a class of compounds with diverse biological activities.
- The combined antiviral effects of AQ and poly r(A-U) have not been fully explored.
Purpose of the Study:
- To investigate the potential of twelve anthraquinones (AQ) to enhance the antiviral activity of polyribo-adenylic-uridylic acid (poly r(A-U)).
- To evaluate the interferon-inducing capacity of AQ/poly r(A-U) combinations.
Main Methods:
- A human foreskin fibroblast-vesicular stomatitis virus bioassay was employed.
- Twelve anthraquinones (AQ) were tested in combination with poly r(A-U) at a specific ratio.
- Antiviral activity and interferon induction were measured.
Main Results:
- Neither poly r(A-U) nor individual AQ showed significant antiviral activity alone.
- Five AQs (mitoxantrone, adriamycin, ametantrone, carminic acid, daunomycin) enhanced poly r(A-U) antiviral activity 9- to 13-fold.
- The interferon-inducing activity of effective combinations equaled the sum of their individual components.
Conclusions:
- Certain anthraquinones (AQ) effectively potentiate the antiviral activity of poly r(A-U).
- This potentiation occurs without the superinduction of interferon.
- These findings suggest potential for novel antiviral strategies combining specific AQ with poly r(A-U).