Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

BLyS and B cell homeostasis.

Robert T Woodland1, Madelyn R Schmidt, Craig B Thompson

  • 1Department of Molecular Genetics and Microbiolgy, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, MA 01655, USA. Robert.Woodland@umassmed.edu

Seminars in Immunology
|August 26, 2006
PubMed
Summary

Naïve B cells require B lymphocyte stimulator (BLyS/BAFF) for survival. This study details BLyS signaling pathways and proposes BLyS enhances B cell responses by optimizing metabolism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emerging roles and regulatory mechanisms involved in glutamine metabolism.

Trends in biochemical sciences·2026
Same author

Ras promotes macropinocytic nutrient uptake by suppressing the albumin recycling receptor FcRn.

EMBO reports·2026
Same author

Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility.

bioRxiv : the preprint server for biology·2026
Same author

Correction: Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis.

The Journal of cell biology·2026
Same author

Corrigendum to Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma.

The Journal of clinical investigation·2025
Same author

Publisher Correction: Metabolic adaptations direct cell fate during tissue regeneration.

Nature·2025

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Naïve peripheral B cells depend on B lymphocyte stimulator (BLyS/BAFF) for survival in vivo.
  • The precise signaling pathways and molecular mechanisms underlying BLyS-mediated B cell survival are not fully understood.

Purpose of the Study:

  • To elucidate the signal cascades involved in BLyS-dependent B cell survival.
  • To investigate the regulation of BLyS-induced signaling pathways.
  • To explore the role of BLyS as a growth factor and its impact on B cell metabolism.

Main Methods:

  • The study discusses existing literature on BLyS signaling.
  • It analyzes signal transduction pathways activated by BLyS.
  • It examines metabolic changes in B cells upon BLyS stimulation.

Related Experiment Videos

Main Results:

  • BLyS activates specific signaling cascades crucial for B cell survival.
  • BLyS signaling is subject to regulatory mechanisms.
  • BLyS acts as a growth factor, enhancing B cell metabolism.

Conclusions:

  • BLyS is essential for maintaining naïve B cell populations through defined signaling pathways.
  • BLyS-induced metabolic enhancement optimizes B cell responses to other immune signals like BCR and TLR.
  • Understanding these mechanisms provides insights into B cell homeostasis and immune responses.