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The role of the BAFF/APRIL system on T cell function
1Department of Immunology and Inflammation, The Garvan Institute of Medical Research, Darlinghurst, NSW, Australia. f.mackay@garvan.org.au
Seminars in Immunology
|August 26, 2006
Summary
B-cell activating factor (BAFF) and APRIL influence T cell function, impacting immune responses like delayed-type hypersensitivity and allergic airway inflammation. Their roles in T cells and B cell interactions are crucial for immunomodulation.
Area of Science:
- Immunology
- Cell Biology
Background:
- B-cell activating factor (BAFF) regulates B cell survival and maturation.
- Overexpression of BAFF is linked to autoimmune disorders and B cell lymphomas.
- Both BAFF and a related ligand, APRIL, are expressed by T lymphocytes and influence their functions.
Purpose of the Study:
- To investigate the role of BAFF and APRIL in T cell activation and survival.
- To explore how BAFF affects T helper 1 (Th1) and T helper 2 (Th2) cell-mediated immune responses.
- To understand the contribution of BAFF-modified B cell compartments to T cell-driven inflammation.
Main Methods:
- Utilized transgenic (Tg) mice with BAFF overexpression.
- Assessed T helper 1 (Th1)-driven delayed-type hypersensitivity (DTH) responses.
- Evaluated T helper 2 (Th2) cell-mediated allergic airway inflammation.
Main Results:
- BAFF overexpression in Tg mice enhanced Th1-driven DTH.
- BAFF overexpression inhibited Th2 cell-mediated allergic airway inflammation.
- Observed that some BAFF effects depend on modifications within the B cell compartment.
Conclusions:
- BAFF and APRIL signaling directly in T cells can modulate T cell functions.
- T cell modulation in response to a BAFF-altered B cell compartment plays a role in inflammation.
- These interactions are significant for understanding broader immunomodulation and inflammatory processes.
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