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Related Experiment Video

Updated: Jul 20, 2026

A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application

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Cryoplasty for arterial restenosis.

S Karthik¹, D J Tuite, A A Nicholson

¹Department of Cardiothoracic Surgery, Leeds General Infirmary, Great George Street, LEEDS LS1 3EX, UK.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery

|August 26, 2006

Summary

Cryoplasty is ineffective for treating arterial restenosis in the iliofemoral segment. Half of the cryoplasty procedures failed within six months, with all failing within one year, indicating a lack of evidence for its use.

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Last Updated: Jul 20, 2026

A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application

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Published on: July 9, 2020

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Area of Science:

Vascular Surgery
Interventional Cardiology
Medical Device Technology

Background:

Arterial restenosis following endovascular treatment poses a significant clinical challenge.
Conventional endovascular methods often result in recurrent stenosis, necessitating further interventions.

Purpose of the Study:

To evaluate the efficacy of cryoplasty in patients with iliofemoral arterial restenosis.
To assess the long-term outcomes of cryoplasty for restenotic lesions after conventional endovascular treatment.

Main Methods:

A prospective follow-up study involving 10 patients with iliofemoral restenosis.
Twelve cryoplasty procedures were performed on patients with prior endovascular treatment and subsequent restenosis.
Doppler ultrasound was used for evaluation at 1, 3, 6, and 12 months post-procedure.

Main Results:

Immediate angiographic success was achieved in all procedures (<30% residual stenosis).
Fifty percent of procedures experienced restenosis within six months, with the remainder developing progressive restenosis between 6-12 months.
Five procedures required re-intervention, and one patient is awaiting surgery due to symptomatic restenosis.

Conclusions:

Cryoplasty demonstrates limited value for treating restenosis in the iliofemoral arterial segment.
High rates of restenosis and need for re-intervention suggest cryoplasty is not a viable option for these lesions.
Current evidence does not support the use of cryoplasty for peripheral arterial restenotic lesions.