Related Experiment Video
Updated: Jul 20, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
Published on: October 31, 2025
Hereditary periodic fever with systemic amyloidosis: is hyper-IgD syndrome really a benign disease?
Rainer Siewert1, Jörg Ferber, Rolf Dieter Horstmann
1Department of Nephrology, Solingen General Hospital, University of Cologne, Solingen, Germany. siewert@klinikumsolingen.de
Abstract:
We report a case of amyloidosis in association with hyperimmunoglobulinemia D syndrome (HIDS). The patient showed typical clinical features of HIDS. He had crescentic glomerulonephritis progressing to end-stage renal disease at age 13 years. Eight years later, he developed an AA-type amyloidosis with extensive involvement of the intestine, respiratory tract, and thyroid gland. These unusual complications of HIDS seriously challenge the assumption that the disease is associated with a good prognosis.
Related Concept Videos
Graves' Disease I: Introduction
Graves Disease II: Pathophysiology
Hypersensitivity Reactions: Immune-Complex Reactions
Rheumatic Heart Disease I: Introduction
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Humoral Immune Responses
