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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...

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Economic evaluations in pain management: principles and methods.

Carl V Asche1, Brian Seal, Kenneth C Jackson

  • 1Pharmacotherapy Outcomes Research Center, Department of Pharmacotherapy, University of Utah College of Pharmacy, 421 Wakara Way, Suite 208, Salt Lake City, UT 84108, USA. carl.asche@pharm.utah.edu

Journal of Pain & Palliative Care Pharmacotherapy
|August 26, 2006
PubMed
Summary

This guide details conducting economic evaluations for pain pharmacotherapy. It outlines six steps for comparing treatment costs and effects, crucial for healthcare decision-making.

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Area of Science:

  • Health Economics
  • Pharmacoeconomics
  • Clinical Trial Analysis

Background:

  • Economic evaluation of pharmacotherapy is increasingly vital for healthcare decision-making.
  • Optimal methods for conducting economic evaluations of therapeutic interventions are needed.
  • Guidance is required for investigators designing, conducting, and reporting these studies.

Purpose of the Study:

  • To provide a comprehensive guide on designing, conducting, and reporting economic evaluations for pain pharmacotherapy.
  • To outline the essential steps for optimal economic evaluation of therapeutic interventions.
  • To clarify the methodologies for comparing pharmacotherapy costs and effects.

Main Methods:

  • Describes the process of economic evaluation, involving comparison of two or more therapeutic interventions.
  • Details five types of economic evaluations: cost-effectiveness, cost-utility, cost-minimization, cost-consequence, and cost-benefit analyses.
  • Outlines six critical steps: defining study perspective, identifying alternatives, identifying costs and effects, data collection, data calculation, and results presentation.

Main Results:

  • Economic evaluations necessitate comparing interventions based on both costs and health effects.
  • The study delineates five distinct methodologies for economic assessment.
  • A structured six-step process is presented for conducting robust economic evaluations.

Conclusions:

  • Implementing a systematic approach to economic evaluation ensures rigorous assessment of pharmacotherapy.
  • Understanding the different types of economic analyses allows for appropriate study design.
  • Clear reporting of costs and effects is essential for informed healthcare policy and clinical practice.