Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring Student Experiences in a Transdisciplinary Clinical Immersion Course on Needs Identification in Veteran and Service Member Healthcare Settings.

Biomedical engineering education·2026
Same author

Homelessness and Risk of End-Stage Kidney Disease and Death in Veterans With Chronic Kidney Disease.

JAMA network open·2024
Same author

Dipole-dipole correlations in the nematic phases of symmetric cyanobiphenyl dimers and their binary mixtures with 5CB.

Soft matter·2023
Same author

Role of Anemia in Dementia Risk Among Veterans With Incident CKD.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2023
Same author

Analysis of urine Raman spectra differences from patients with diabetes mellitus and renal pathologies.

PeerJ·2023
Same author

Age-Related Association between Multimorbidity and Mortality in US Veterans with Incident Chronic Kidney Disease.

American journal of nephrology·2022

Related Experiment Video

Updated: Jul 20, 2026

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells
06:23

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells

Published on: November 21, 2025

Drug-associated renal dysfunction and injury.

Devasmita Choudhury1, Ziauddin Ahmed

  • 1University of Texas Southwestern Medical Center, Dallas, TX, USA. devasmita.dev@med.va.gov

Nature Clinical Practice. Nephrology
|August 26, 2006
PubMed
Summary

Medications commonly cause kidney dysfunction and failure through various mechanisms. Early detection and prevention of drug-induced kidney injury (DIKI) are crucial.

Area of Science:

  • Nephrology
  • Pharmacology
  • Toxicology

Background:

  • Medication-induced kidney dysfunction is a frequent clinical issue.
  • Drugs can impair renal function through reduced perfusion or direct cellular damage.
  • Recognizing drug-induced kidney injury (DIKI) is vital for patient outcomes.

Purpose of the Study:

  • To review the clinical features of DIKI.
  • To explain the underlying mechanisms of DIKI.
  • To highlight the importance of early detection and prevention of DIKI.

Main Methods:

  • Literature review of common medications causing renal injury.
  • Analysis of mechanisms of renal injury.
  • Correlation of clinical presentations with specific drug classes.

More Related Videos

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury
07:02

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Published on: February 10, 2026

Related Experiment Videos

Last Updated: Jul 20, 2026

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells
06:23

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells

Published on: November 21, 2025

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury
07:02

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Published on: February 10, 2026

Main Results:

  • Drugs can cause kidney injury by affecting renal perfusion, leading to reduced filtration.
  • Direct cellular injury can manifest as acute tubular necrosis, interstitial nephritis, and other syndromes.
  • Specific clinical findings include microangiopathy, Fanconi syndrome, and electrolyte abnormalities.

Conclusions:

  • Understanding DIKI mechanisms is essential for early diagnosis.
  • Recognizing clinical presentations aids in timely intervention.
  • Preventing DIKI requires awareness of drug effects on renal function.