Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Noise Reduction for Low-Dose Single-Slice Helical CT Sinograms.

Jing Wang1, Tianfang Li, Hongbing Lu

  • 1J. Wang and Z. Liang are with the Departments of Radiology and Physics and Astronomy, State University of New York, Stony Brook, NY 11794 USA (telephone: 631-444-2736, e-mail: jzl@mil.sunysb.edu ).T. Li and H. Lu were with the Department of Radiology, State University of New York, Stony Brook, NY 11794 USA. T. Li is now with the Department of Radiation Oncology, Stanford University, Stanford, CA 94305 USA. H. Lu is now with the Department of Biomedical Engineering, the Fourth Military Medical University, Xi'An, Shaanxi 710032, China.

IEEE Transactions on Nuclear Science
|August 26, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A two-stage workflow for vitiligo diagnosis: clinical characteristic classification and large language model (LLM)-based report generation.

Frontiers in immunology·2026
Same author

Trans-10, cis-12 conjugated linoleic acid modulates offspring hepatic lipid metabolism by activating AMPK pathway associated with altered gut microbiota.

Biochimica et biophysica acta. Molecular and cell biology of lipids·2026
Same author

X-optogenetic inhibition of VTA GABA neurons for wireless deep-brain stimulation and suppression of scratching behavior in freely moving mice.

Materials today. Bio·2026
Same author

Robust and High-Performance Self-Rectifying Memristors Featuring a-WO<sub>3</sub>/a-IGZO Heterostructures for Reliable Artificial Synaptic Applications.

The journal of physical chemistry letters·2026
Same author

Simulation-Based X-Ray Spectrum Optimization for Dose Enhancement in X-Ray-Induced Photodynamic Therapy with NaLuF<sub>4</sub>:20% Gd, 15% Tb<sup>3+</sup> Nanocrystals.

Bioengineering (Basel, Switzerland)·2026
Same author

Diff-PCGS: physics-constrained Gaussian splatting with diffusion denoising for fast sparse-view XFCT imaging.

Physics in medicine and biology·2026

This study introduces a novel noise reduction technique for helical computed tomography (HCT) by lowering X-ray dose and filtering sinogram data. The method significantly improves image quality and defect detection in HCT scans.

Area of Science:

  • Medical Imaging
  • Radiological Physics
  • Computational Imaging

Background:

  • Helical computed tomography (HCT) offers advantages for dynamic imaging but increases radiation exposure.
  • Reducing X-ray dose in HCT is crucial for patient safety and repeated scans.
  • Noise in low-dose HCT sinograms can degrade image quality and diagnostic accuracy.

Purpose of the Study:

  • To develop and validate a noise reduction method for low-dose helical computed tomography (HCT).
  • To improve image quality and defect detectability in HCT by reducing sinogram noise.
  • To enable dose reduction in HCT without compromising diagnostic performance.

Main Methods:

  • Utilized three key observations of HCT noise characteristics: continuous axial sampling, Gaussian noise distribution post-calibration, and mean-variance relationships.

Related Experiment Videos

  • Developed a penalized weighted least-squares (PWLS) solution incorporating a mean-variance derived weight.
  • Employed Karhunen-Loève (KL) transform along the axial direction for SNR-adaptive noise reduction.

    • Main Results:

    • The proposed KL-PWLS method demonstrated effective noise reduction in HCT sinograms.
    • Simulation studies showed significant improvements in image quality compared to conventional methods.
    • Enhanced defect detectability was observed with the KL-PWLS noise reduction technique.

    Conclusions:

    • The KL-PWLS method provides an efficient and effective approach to reduce noise in low-dose HCT.
    • This technique allows for significant radiation dose reduction while maintaining or improving image quality.
    • The findings support the clinical applicability of low-dose HCT with advanced noise reduction for enhanced diagnostic imaging.