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AMG 531: an investigational thrombopoiesis-stimulating peptibody
1Amgen, Inc., Thousand Oaks, California 91320, USA. jnichol@amgen.com
Pediatric Blood & Cancer
|August 26, 2006
Abstract:
Thrombopoietin (TPO) regulates megakaryopoiesis and the generation of platelets. Recombinant TPO has been investigated in clinical studies for use in thrombocytopenia with limited success. A new peptibody, AMG 531, has been shown to increase platelet counts in preclinical and Phase 1 and Phase 2 studies and to be generally safe and tolerable in those studies.

