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Updated: Jul 20, 2026

Escherichia coli -Based Complementation Assay to Study the Chaperone Function of Heat Shock Protein 70
Published on: March 8, 2024
A new role for CCR5 in innate immunity--binding to bacterial heat shock protein 70
Charles R Mackay1, Federica Sallusto
1Immunology and Inflammation Department, Garvan Institute of Medical Research, Darlinghurst, Australia. c.mackay@garvan.org.au
Abstract:
CCR5 has been associated with adaptive immune responses, because of its expression on effector and memory T cells, and dentric cells. In this issue of the European Journal of Immunology, Whittall et al. identify CCR5 as a receptor that binds bacterial heat shock protein 70 (HSP70). Thus HSP70 may stimulate responses by CCR5+ T cells or dendritic cells, particularly at epithelial surfaces. These findings imply a role for CCR5 in innate immunity, in addition to its more established role as a chemoattractant receptor for adaptive immune responses.
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