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Updated: Jul 20, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
[Distribution of single nucleotide polymorphisms of IL-10 gene in patients with mucoviscidosis]
Abstract:
Distribution of interleukin-10 promoter-1082 G-->A single nucleotide polimorphism (SNP) in the group of cystic fibrosis (CF) patients has been studied. As a whole 42 CF patients and 73 persons of the control group were genotyped for IL-10 promoter-1082 G-->A SNP. The frequences of IL-10-1082 G-allele and GG high expression genotype increased significantly in CF patients in comparison to the control group. In addition, study of IL-10-1082 SNP distribution in the separate CF groups showed statistically significant increasing of the G-allele and GG-genotype frequencies in the subgroup of homozygous delF508 cariers. The possible role of IL-10 promoter SNP as a phenotype modifiers at different CF genotypes is examined.
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