Steroidal saponins from Solanum nigrum
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Updated: Jul 20, 2026

Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
Xinlan Zhou1, Xiangjiu He, Guanghui Wang
1Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
Abstract:
Six new steroidal saponins, solanigrosides C-H (2-7), and one known saponin, degalactotigonin (1), were isolated from the whole plant of Solanum nigrum. Their chemical structures were elucidated using spectroscopic analysis, chemical degradation, and derivatization. All seven compounds were tested for their cytotoxicity using four human tumor cell lines (HepG2, NCI-H460, MCF-7, SF-268). Only compound 1 was cytotoxic, with IC50 values of 0.25-4.49 microM.
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