Related Experiment Video
Updated: Jan 9, 2026
Pulmonary Embolism III: Nursing Management
Published on: June 19, 2025
KIR/HLA pleiotropism: protection against both HIV and opportunistic infections
Ying Qi1, Maureen P Martin, Xiaojiang Gao
1Laboratory of Genomic Diversity, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland, USA.
Abstract:
The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific defense against opportunistic infections, but not AIDS-related malignancies. The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS.
Related Concept Videos
Pulmonary Embolism III: Nursing Management
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Pulmonary Embolism I: Introduction
Venous Thrombosis III: Interprofessional Care
Pneumothorax-II
Clinical Manifestations:
Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation