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Updated: Jul 20, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Secondary prevention of arteriosclerosis in lower limb vascular amputees: a missed opportunity
1Disablement Services Centre, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
Objectives:
To determine the numbers of patients with peripheral vascular disease prescribed secondary prevention agents following a lower limb amputation.
Design:
A retrospective cross sectional study.
Methods:
The clinical documentation of 107 vascular amputees (mean age 69.5, 2:1 male:female ratio) referred for prosthesis provision in 2004 and 2005 were analysed to determine levels of prescribing of anti-platelet agents, anti-coagulants and cholesterol lowering drugs.
Results:
Analysis of vascular amputees referred in 2004 and 2005 reveals that 41% were prescribed a statin and 39% were prescribed a statin and 60% an anti-platelet agent. While 39% of these patients were on both drugs, 32% had been prescribed neither.
Conclusions:
The medical management of patients with severe peripheral vascular disease, even where their disease has led to an amputation, is sub-optimal.
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