Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transcriptomic changes in developing kidney exposed to chronic hypoxia.

Dumitru A Iacobas1, Chenhao Fan, Sanda Iacobas

  • 1Department of Neuroscience, Kennedy Center, Room #915C, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, New York, NY 10461, USA. diacobas@aecom.yu.edu

Biochemical and Biophysical Research Communications
|August 29, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vivo characterization of a patient CACNA1A variant reveals paradoxical synaptic effects.

bioRxiv : the preprint server for biology·2026
Same author

Farnesoid X receptor-dependent microbiome-bile acid signaling mediates obstructive sleep apnea-induced atherosclerosis.

bioRxiv : the preprint server for biology·2026
Same author

Mitochondrial Collapse Responsible for Chagasic and Post-Ischemic Heart Failure Is Reversed by Cell Therapy Under Different Transcriptomic Topologies.

Current issues in molecular biology·2025
Same author

Integrated multiomics reveals inflammation-driven excessive erythrocytosis in subjects with Monge's disease.

bioRxiv : the preprint server for biology·2025
Same author

Neurotransmission Sex Dichotomy in the Rat Hypothalamic Paraventricular Nucleus in Healthy and Infantile Spasm Model.

Current issues in molecular biology·2025
Same author

Klinefelter syndrome: A neurodevelopmental disease of the synapse.

Neurobiology of disease·2025
Same journal

A transferrin receptor-based vector enables robust Type-II membrane protein display on mammalian cells.

Biochemical and biophysical research communications·2026
Same journal

NAT10-mediated RNA N4-acetylation promotes intestinal fibroblast senescence via DHRS2.

Biochemical and biophysical research communications·2026
Same journal

Deciphering potent MPL activation by the fucose-binding lectin thrombocorticin.

Biochemical and biophysical research communications·2026
Same journal

Mitochondrial genome alterations in cancer: From mutations and epigenetics to targeted therapiesack.

Biochemical and biophysical research communications·2026
Same journal

GPC3 chimeric antigen receptor (CAR)-NK cells combined with Enoblituzumab enhance the anti-tumor efficacy against hepatocellular carcinoma.

Biochemical and biophysical research communications·2026
Same journal

A miR-382-5p-PORCN axis modulates endogenous Wnt signaling during palatal development.

Biochemical and biophysical research communications·2026
See all related articles

Chronic hypoxia (CCH) and intermittent hypoxia (CIH) in neonatal mice alter kidney gene expression and retard maturation. CCH caused more profound changes than CIH, affecting pH regulation and growth pathways.

Area of Science:

  • Neonatal physiology
  • Molecular biology
  • Genomics

Background:

  • Hypoxia, a condition of low oxygen, significantly impacts neonatal development.
  • Understanding the molecular mechanisms underlying hypoxia's effects is crucial for clinical interventions.

Purpose of the Study:

  • To compare the effects of chronic constant hypoxia (CCH) and chronic intermittent hypoxia (CIH) on neonatal mouse kidney gene expression.
  • To investigate the impact of these hypoxia types on kidney maturation and related pathways.

Main Methods:

  • Gene expression profiling using cDNA arrays in neonatal mouse kidneys.
  • Comparison between CCH, CIH, and normoxic control groups at 1, 2, and 4 weeks.
  • Analysis of gender-specific gene expression patterns.

Related Experiment Videos

Main Results:

  • CCH and CIH altered 5-20% of genes, with CCH inducing greater changes.
  • CCH strongly activated pH-controlling pathways, indicated by solute carrier gene upregulation.
  • Reduced expression changes in growth and development genes suggest retarded maturation in both hypoxia types.
  • Gender-dependent gene regulation was observed, varying with time and hypoxia type.
  • Transcriptional control was enhanced in CCH but not CIH.

Conclusions:

  • Both CCH and CIH disrupt neonatal kidney gene expression and maturation.
  • CCH induces more significant molecular alterations than CIH.
  • Hypoxia-induced changes in pH regulation, growth, and development pathways are critical areas for further research.